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ProductsBack/TET1 antibody [N1], N-term - KO/KD Validated
GTX125888 WB Image
GTX125888 WB Image
GTX125888 WB Image

TET1 antibody [N1], N-term - KO/KD Validated

Research Use Only
GTX125888
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
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Product group Antibodies
ReactivityHuman, Mouse
Price on request
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Overview

  • Supplier
    GeneTex
  • Product Name
    TET1 antibody [N1], N-term - KO/KD Validated
  • Delivery Days Customer
    10
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells. Chrysanthou S et al., 2018 Apr 10, Stem Cell Reports
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  • Coordination of germ layer lineage choice by TET1 during primed pluripotency. Luo X et al., 2020 Apr 1, Genes Dev
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  • Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte. Hill PWS et al., 2018 Mar 15, Nature
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  • Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naive embryonic stem cells. Coluccio A et al., 2018 Feb 26, Epigenetics Chromatin
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  • Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism. Bai M et al., 2018 Oct, Oncogene
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  • miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs. Cui Y et al., 2016 Oct 4, Oncotarget
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  • Regulatory Dynamics of Tet1 and Oct4 Resolve Stages of Global DNA Demethylation and Transcriptomic Changes in Reprogramming. Bartoccetti M et al., 2020 Feb 18, Cell Rep
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  • Reprogramming competence of OCT factors is determined by transactivation domains. Kim KP et al., 2020 Sep, Sci Adv
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  • Reprogramming competence of OCT factors is determined by transactivation domains. Kim KP et al., 2020 Sep, Sci Adv
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  • Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Kang J et al., 2015 Aug 4, Proc Natl Acad Sci U S A
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