TLR4 Polyclonal Antibody

Catalog number: GRP624
Brand: German Research Products
Packing: 100 ul
Price: € 399.00
Expected delivery time: 14 days
Quantity:

Product specifications for - TLR4 Polyclonal Antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot, IHC-P
Species: Human, Rat
Host: Rabbit
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Properties: 
  Research Use Only
UNSPSC: 12352203
Storage instructions: Store at -20-¦C for 12 months.
Scientific information: 
Scientific info: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- (PubMed:23880187).
Additional information: 
Synonyms: GRP624; German Research Products