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GTX70255 WB Image
GTX70255 WB Image
GTX70255 WB Image

TSG101 antibody [4A10] - KO/KD, Orthogonal Validated

Research Use Only
GTX70255
GeneTex
ApplicationsElectron Microscopy, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Hamster, Human, Monkey, Mouse, Porcine, Rat
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    TSG101 antibody [4A10] - KO/KD, Orthogonal Validated
  • Delivery Days Customer
    10
  • Applications
    Electron Microscopy, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    4A10
  • Concentration
    1.8 mg/ml
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
  • Reactivity
    Canine, Hamster, Human, Monkey, Mouse, Porcine, Rat
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Koester S et al., 2017 Oct 10, Proc Natl Acad Sci U S A
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  • A combined miRNA-piRNA signature to detect Alzheimers disease. Jain G et al., 2019 Oct 7, Transl Psychiatry
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  • A targeted spatial-temporal proteomics approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation. Moorman NJ et al., 2010 May, Mol Cell Proteomics
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  • Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules. Boussadia Z et al., 2018 Oct 5, J Exp Clin Cancer Res
    Read more
  • AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Strack B et al., 2003 Sep 19, Cell
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  • Alix regulates cortical actin and the spatial distribution of endosomes. Cabezas A et al., 2005 Jun 15, J Cell Sci
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  • Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus. Batool A et al., 2019, Front Neurosci
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  • Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid beta (Abeta) production in the trans-Golgi network. Choy RW et al., 2012 Jul 24, Proc Natl Acad Sci U S A
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  • An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Gullapalli A et al., 2006 Mar, Mol Biol Cell
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  • Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. Colombo M et al., 2013 Dec 15, J Cell Sci
    Read more