GTX70255 WB Image
TSG101 antibody [4A10] - KO/KD, Orthogonal Validated
GTX70255
ApplicationsElectron Microscopy, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Hamster, Human, Monkey, Mouse, Porcine, Rat
Overview
- SupplierGeneTex
- Product NameTSG101 antibody [4A10] - KO/KD, Orthogonal Validated
- Delivery Days Customer10
- ApplicationsElectron Microscopy, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID4A10
- Concentration1.8 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
- ReactivityCanine, Hamster, Human, Monkey, Mouse, Porcine, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid beta (Abeta) production in the trans-Golgi network. Choy RW et al., 2012 Jul 24, Proc Natl Acad Sci U S ARead more
- An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Gullapalli A et al., 2006 Mar, Mol Biol CellRead more
- Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. Colombo M et al., 2013 Dec 15, J Cell SciRead more