Antitumor agent-171 [3003004-76-7]

TargetMol Chemicals

Antitumor agent-171 [3003004-76-7]

9

Research Use Only

C35H45N7O5

643.78

Antitumor agent-171 (Compound 35) acts as an inhibitor of the beta-catenin/BCL9 interaction, with an IC50 of 1.61 microM. It suppresses the expression of the axin2 gene, demonstrating an IC50 value of 0.84 microM, and exhibits high affinity for beta-catenin with a Kd of 0.63 microM. Additionally, Antitumor agent-171 inhibits the viability of HCT116 cells with an IC50 of 4.39 microM. It activates T cells, enhances antigen presentation, and shows antitumor activity and favorable pharmacokinetic properties in murine models.

N(CC1=CC=C(C=C1)C=2C=NNC2)(C(N[C@@H]3CN(CCC3)C4=CC(OC(C(NCC(=O)N5CC[C@H](O)C5)=O)(C)C)=CC=C4)=O)C6CC6

-20°C

12352200