Antitumor agent-171

MedChem Express

Antitumor agent-171

5

Research Use Only

98.48

C35H45N7O5

643.78

Antitumor agent-171 (Compound 35) is an inhibitor for beta-catenin/BCL9 interaction with IC 50 of 1.61 microM. Antitumor agent-171 exhibits high affinity to beta-catenin with K d of 0.63 microM. Antitumor agent-171 inhibits the gene expression of axin2 with IC 50 of 0.84 microM. Antitumor agent-171 inhibits cell viability of HCT116 with IC 50 of 4.39 microM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models [1] .

O=C(C(C)(OC1=CC(N2CCC[C@@H](C2)NC(N(CC3=CC=C(C=C3)C4=CNN=C4)C5CC5)=O)=CC=C1)C)NCC(N6CC[C@@H](C6)O)=O

-20°C,2°C to 8°C

12352200