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AP 811 [124833-45-0]

Research Use Only
T38641
TargetMol Chemicals
CAS Number124833-45-0
DownloadMSDS
Product group Chemicals
Molecular Weight915.11
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    AP 811 [124833-45-0]
  • Delivery Days Customer
    16
  • CAS Number
    124833-45-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    AP 811
  • Molecular Formula
    C46H66N12O8
  • Molecular Weight
    915.11
  • Scientific Description
    AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.
  • Shelf life instruction
    3 years
  • SMILES
    CCC(C)CNC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(C)CC
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Veale CA, et al. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000;10(17):1949-1952.
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