AP23464

MedChem Express

AP23464

9

Research Use Only

C26H30N5O2P

475.52

AP23464 is an ATP-based inhibitor for Kit , that inhibits the phosphorylation of Kit wildtype and mutants, with IC 50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells ( IC 50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells [1] .

O=P(C)(C)C1=CC=C(NC2=NC(C3CCCC3)=NC4=C2N=CN4CCC5=CC(O)=CC=C5)C=C1

12352200