Western Blot analysis of Hela cell using APAF1 Polyclonal Antibody at dilution of 1:350
APAF1 Polyclonal Antibody
E-AB-12215
Product group Antibodies
Overview
- SupplierElabscience
- Product NameAPAF1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA WB IHC
- CertificationResearch Use Only
- Concentration0.7mg/ml
- Scientific DescriptionThis gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
- UNSPSC12352203