APC Anti-Mouse CD105 Antibody

Reddot Biotech

APC Anti-Mouse CD105 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

MJ7/18

APC

Eng

endoglin

AI528660; AI662476; CD105; cell surface MJ7/18 antigen; En; Endo; endoglin; S-endoglin; transmembrane glycoprotein

Rat

IgG2a

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-beta1, TGF-beta3 and modulates TGF-beta signaling by interacting with TGF-beta receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.

Mouse

2°C to 8°C

12352203