APEX Nuclease I(CPTC-APEX1-2), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

APEX Nuclease I(CPTC-APEX1-2), CF405S conjugate, 0.1mg/mL

9

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

CPTC-APEX1-2

0.1 mg/ml

Other Conjugate

APEX1

apurinic/apyrimidinic endodeoxyribonuclease 1

AP endonuclease class I; AP lyase; APE; APE1; APEN; APEX; APEX nuclease (multifunctional DNA repair enzyme) 1; apurinic/apyrimidinic (abasic) endonuclease; apurinic-apyrimidinic endonuclease 1; APX; deoxyribonuclease (apurinic or apyrimidinic); DNA-(apurinic or apyrimidinic site) endonuclease; DNA-(apurinic or apyrimidinic site) lyase; HAP1; protein REF-1; redox factor-1; REF1

Mouse

IgG1

DNA-(apurinic or apyrimidinic site) lyase

APEX Nuclease (also known as APEX1 or APE1) is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are in DNA repair and redox regulation of transcriptional factors. It functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Patients with genetic variants in APEX1 have been shown to have a higher risk of lung cancer. Elevated APEX1 levels observed in human testicular cancer may be related to relative resistance to therapy and therefore may serve as a diagnostic marker for refractory disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203