WB analysis of RAW264.7 cell lysate using GTX85062 APH1A antibody. Working concentration : (A) 0.5, (B) 1, and (C) 2 microg/ml
WB analysis of RAW264.7 cell lysate using GTX85062 APH1A antibody. Working concentration : (A) 0.5, (B) 1, and (C) 2 microg/ml
APH1A antibody
GTX85062
Overview
- SupplierGeneTex
- Product NameAPH1A antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 0.5 - 2 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- Concentration1 mg/ml
- FormulationLiquid
- Gene ID51107
- Target nameAPH1A
- Target descriptionaph-1 homolog A, gamma-secretase subunit
- Target synonyms6530402N02Rik; anterior pharynx defective 1 homolog A; APH-1; APH-1A; APH1A gamma secretase subunit; aph-1alpha; CGI-78; gamma-secretase subunit APH-1A; presenilin-stabilization factor
- Protein IDQ96BI3
- Protein NameGamma-secretase subunit APH-1A
- Scientific DescriptionAPH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gammasecretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma and epsilonsites and can lead to the accumulation of the Amyloid betapeptide Abetacleavage product that is associated with Alzheimers disease. APH1 exists in at least three distinct isoforms with APH1alpha as the principal isoform present in the gammasecretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. Despite its predicted molecular weight, APH1 protein often migrates at aberrant locations in SDS-PAGE.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203