Apicidin [183506-66-3]
A6132
Overview
- SupplierLKT Laboratories
- Product NameApicidin [183506-66-3]
- Delivery Days Customer7
- Estimated Purity≥98%
- FormatEthano (0.9 mg/mL)l, DMSO (0.9 mg/mL), Dichloromethane.; Slightly soluble in water, methanol
- Scientific DescriptionCyclic tetrapeptide; HDAC inhibitor.
- Storage Instruction4°C
- UNSPSC12352200
References
- Ahn MY, Ahn SG, Yoon JH. Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells. Oral Oncol. 2011 Nov;47(11):1032-8. PMID: 21856210. Brazelle W, Kreahling JM, Gemmer J, et al. Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells. PLoS One. 2010 Dec 14;5(12):e14335. PMID: 21179472. Kankaanranta H, Janka-Junttila M, Ilmarinen-Salo P, et al. Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils. J Inflamm (Lond). 2010 Feb 4;7:9. PMID: 20181093. Cheong JW, Chong SY, Kim JY, et al. Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells. Clin Cancer Res. 2003 Oct 15;9(13):5018-27. PMID: 14581377.