Apitolisib

Biorbyt

Apitolisib [1032754-93-0]

16

1032754-93-0

Research Use Only

C23H30N8O3S

498.6011

GDC-0980 (RG7422) is a potent, class I PI3K inhibitor for PI3Kalpha/beta/delta/gamma with IC50 of 5 nM/27 nM/7 nM/14 nM, respectively. Also a mTOR inhibitor with Ki of 17 nM, and highly selective versus others PIKK family kinases.

C[C@H](O)C(N1CCN(CC2=C(C)C3=NC(C4=CN=C(N)N=C4)=NC(N5CCOCC5)=C3S2)CC1)=O

12352200