aPKC-IN-2

MedChem Express

aPKC-IN-2 [15854-08-7]

9

15854-08-7

Research Use Only

99.80

C14H15NO2S

261.34

aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFkappaB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors[1].

O=C(C1=C(SC=C1C2=CC=C(C=C2)C)N)OCC

-20°C

12352200