Apricitabine [160707-69-7]

TargetMol Chemicals

Apricitabine [160707-69-7]

9

160707-69-7

Chemical

Research Use Only

Apricitabine

C8H11N3O3S

229.26

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 microM), the (-) enantiomer of 2-deoxy-3-oxy-4-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase alpha, beta and gamma with Ki values of 300 microM, 12 microM and 112.25 microM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.

3 years

O=C1N([C@@H]2S[C@H](CO)OC2)C=CC(N)=N1

-20°C

12352200