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ProductsBack/Arglabin [84692-91-1]
Chemical Structure
Chemical Structure
Chemical Structure

Arglabin [84692-91-1]

Research Use Only
AG-CN2-0458
AdipoGen Life Sciences
CAS Number84692-91-1
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight246.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Arglabin [84692-91-1]
  • Delivery Days Customer
    10
  • CAS Number
    84692-91-1
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C15H18O3
  • Molecular Weight
    246.3
  • Scientific Description
    Anticancer compound. Farnesyltransferase inhibitor. Potent anti-inflammatory agent. NF-kappaB inhibitor. Inflammasome inhibitor. Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries. - Chemical. CAS: 84692-91-1. Formula: C15H18O3. MW: 246.3. Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora. Anticancer compound. Farnesyltransferase inhibitor. Potent anti-inflammatory agent. NF-kappaB inhibitor. Inflammasome inhibitor. Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
  • SMILES
    [H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall: C. Bottex-Gauthier, et al.; Biotechnol. Ther. 4, 77 (1993)
  • Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase: T.E. Shaikenov, et al.; Oncol. Rep. 8, 173 (2001)
  • Biomimetic semisynthesis of arglabin from parthenolide: J.D. Zhai, et al.; JOC 77, 7103 (2012)
  • Synthesis and biological evaluation of antitumor-active arglabin derivatives: R. Csuk, et al.; Arch Pharm. 345, 215 (2012)
  • Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-kappaB activation and MCP-1 and TGF-beta1 expression in rat mesangial cells: Q.Q. Jia, et al.; Molecules 18, 13061 (2013)
  • Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin: S.H. Lone & K.A. Bhat; THL 56, 1908 (2015)
  • Anti-Inflammatory and antiatherogenic effects of the NLRP3 Inflammasome inhibitor Arglabin in ApoE2.Ki mice fed a high-fat diet: A. Abderrazak, et al.; Circulation 131, 1061 (2015)