ARNT2 Polyclonal Antibody

Reddot Biotech

ARNT2 Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

ARNT2

aryl hydrocarbon receptor nuclear translocator 2

ARNT protein 2; aryl hydrocarbon receptor nuclear translocator 2; bHLHe1; class E basic helix-loop-helix protein 1; WEDAS

Rabbit

IgG

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.

Human, Mouse, Rat

-20°C

12352203