AS2863619 free base [2241300-50-3]
T10382
CAS Number2241300-50-3
Product group Chemicals
Molecular Weight332.32
Overview
- SupplierTargetMol Chemicals
- Product NameAS2863619 free base
- Delivery Days Customer72
- CAS Number2241300-50-3
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameAS2863619 free base
- Molecular FormulaC16H12N8O
- Molecular Weight332.32
- Scientific DescriptionAS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM). STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.
- Shelf life instruction3 years
- SMILESCc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N
- Storage Instruction-20°C
- UNSPSC12352200