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ProductsBack/Asperphenamate [63631-36-7]
Chemical Structure
Chemical Structure
Chemical Structure

Asperphenamate [63631-36-7]

Research Use Only
AG-CN2-0171
AdipoGen Life Sciences
CAS Number63631-36-7
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight506.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Asperphenamate [63631-36-7]
  • Delivery Days Customer
    10
  • CAS Number
    63631-36-7
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C32H30N2O4
  • Molecular Weight
    506.6
  • Scientific Description
    Anticancer compound. Cytotoxic against human breast cancer cells. Induces autophagic cell death in MCF-7 cells. Moderate radical scavenger. Weak acetylcholinesterase (AChE) inhibitor. Shows moderate trypanocidal activity. - Chemical. CAS: 63631-36-7. Formula: C32H30N2O4. MW: 506.6. Isolated from Aspergillus sp. Anticancer compound. Cytotoxic against human breast cancer cells. Induces autophagic cell death in MCF-7 cells. Moderate radical scavenger. Weak acetylcholinesterase (AChE) inhibitor. Shows moderate trypanocidal activity.
  • SMILES
    O=C(OC[C@@H](CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1)[C@@H](CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Two metabolites from Aspergillus flavipes: A.M. Clark, et al.; Lloyda 40, 146 (1977)
  • Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis: P.W. Wu, et al.; Chem. Pharm. Bull. 52, 345 (2004)
  • A new method for asperphenamate synthesis and its antimicrobial activity evaluation: A.M. Pomini, et al.; Nat. Prod. Res. 20, 537 (2006)
  • Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine: L. Yuane, et al.; Chin. Chem. Lett. 21, 155 (2010)
  • JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells: Y. Li, et al.; Toxicol. Appl. Pharmacol. 263, 21 (2012)
  • Two new Penicillium species Penicillium buchwaldii and Penicillium spathulatum, producing the anticancer compound asperphenamate: J.C. Frisvad, et al.; FEMS Microbiol. Lett. 339, 77 (2013)
  • In vitro acetylcholinesterase activity of peptide derivatives isolated from two species of Leguminosae: C.Q. Alves, et al.; Pharm. Biol. 51, 936 (2013)
  • Antioxidant activity of compounds isolated from the root woods of Erythrina droogmansiana: A.J.G. Yaya, et al.; Int. J. Pharm. Sci. Drug Res. 6, 160 (2014)
  • Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae): N.J. Nwodo, et al.; Molecules 19, 5470 (2014)