c-CBL TR-FRET Assay Kit

Catalog number: 79786
Brand: BPS Bioscience
Packing: 384 reactions
Price: € 2192.00
Expected delivery time: 7 days

Product specifications for - c-CBL TR-FRET Assay Kit

Product group: Assays
Category: Cell based assays
Subcategory: Characterization
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116133
Storage instructions: See Manual
Scientific information: 
Scientific info: Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. c-Cbl is a ubiquitously expressed mammalian protein that plays a vital role in fundamental cellular functions including cell survival, migration, and proliferation. Recent evidence suggests a critical role for c-Cbl in angiogenesis and human solid organ tumors, making it a potential drug target in cancer immunotherapy. The c-CBL TR-FRET Assay Kit is designed to measure c-CBL auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes Biotin-labeled Ubiquitin and a terbium-labeled anti-c-CBL antibody to complete the TR-FRET pairing. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications.
Additional information: 
Synonyms: 79786; BPS Bioscience