CBL-B TR-FRET Assay Kit

Catalog number: 79575
Brand: BPS Bioscience
Packing: 384 reactions
Price: On Request
Expected delivery time: 7 days
Quantity:

Product specifications for - CBL-B TR-FRET Assay Kit

Overview: 
Product group: Assays
Category: Cell based assays
Subcategory: Characterization
Application note: Great for screening small molecular inhibitors for drug discovery and HTS applications.
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116133
Form supplied: The CBL-B TR-FRET Assay Kit is designed to measure CBL-B auto-ubiquitination activity in a homogeneous 384 reaction format.
Storage instructions: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Scientific information: 
Scientific info: Human Casitas B-lineage lymphoma proto-oncogene b (CBL-B) is an E3 ubiquitinprotein ligase that functions as a negative regulator of T-cell activation. It is a promising drug target in cancer immunotherapy. The CBL-B TR-FRET Assay Kit is designed to measure CBL-B auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes biotin-labeled Ubiquitin and a terbium-labeled anti-CBL-B antibody to complete the TR-FRET pairing. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications.
Additional information: 
Synonyms: 79575; BPS Bioscience
Jeon, M.S., et al., Immunity. 2004, 21(2): 167-177 Read more
Chiang, Y.J. et al., Nature. 2000, 403: 216-220 Read more