Irisin Competitive ELISA Kit

Catalog number: AG-45A-0046YEK-KI01
Brand: AdipoGen Life Sciences
Packing: 96 wells
Price: € 590.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Irisin Competitive ELISA Kit

Overview: 
Product group: Assays
Category: ELISA / EIA
Application: ELISA
Species: Human, Monkey, Mouse, Rat
Target: FNDC5
Target description: fibronectin type III domain containing 5
Properties: 
Assay Sensitivity: 1ng/ml
Assay Detection Range: 0.001 - 5 microg/ml
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Storage instructions: 2-¦C to 8-¦C
Scientific information: 
Scientific info: ELISA Assay. Detects human irisin. It should also work in mouse, rat and monkey biological samples. Does not cross-react with FNDC4, human adiponectin, human Nampt, human RBP4, human clusterin, human leptin, human vaspin, human GPX3, human resistin, human ACE2, human lipocalin-2, human ANGPTL3, human ANGPTL6, human DNER, human DLK1, human calreticulin, human IL-33, mouse Nampt, mouse clusterin, mouse vaspin or mouse resistin. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 0.001 - 5 microg/ml. Sensitivity: 1ng/ml. Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Circulating irisin levels were shown to be upregulated after acute exercise. Increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance. - Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Circulating irisin levels were shown to be upregulated after acute exercise. Increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance.
Gene ID: 252995
Swiss prot ID: Q8NAU1
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-45A-0046YEK-KI01; AdipoGen Life Sciences; fibronectin type III domain-containing protein 5; fibronectin type III repeat-containing protein 2; FRCP2; irisin
Oxytocin secretion is related to measures of energy homeostasis in young amenorrheic athletes: E.A. Lawson, et al.; J. Clin. Endocrinol. Metab. 99, E881 (2014) Read more
Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans: H.Y. Choi, et al.; J. Clin. Endocrinol. Metab. 99, 2778 (2014) Read more
Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates: V. Singhal, et al.; PLoS One 9, e100218 (2014) Read more
Circulating sclerostin and irisin are related and interact with gender to influence adiposity in adults with prediabetes: T. Klangjareonchai, et al.; Int. J. Endocrinol. 2014, ID261545 (2014) Read more
Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients: M.J. Lee, et al.; Atheroscler. 242, 476 (2015) Read more
Irisin levels in the progression of diabetes in sedentary women: I.D. Duran, et al.; Clin. Biochem. 48, 1268 (2015) Read more
The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype: Y.C. Hwang, et al.; Cardiovasc. Diabetol. 15, 9 (2016) Read more
Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization: J.E. Blevins, et al.; Am. J. Physiol. 310, R640 (2016) Read more
Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes: M. Pahlavanni, et al.; J. Nutr. Bioche. 39, 101 (2017) Read more