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Western blot analysis of extracts from HeLa cells and 293 cells, using ATF-2 (Ab-472) antibody.
Western blot analysis of extracts from HeLa cells and 293 cells, using ATF-2 (Ab-472) antibody.
Western blot analysis of extracts from HeLa cells and 293 cells, using ATF-2 (Ab-472) antibody.

ATF2 (Ab-472) Antibody

Research Use Only
CSB-PA557506
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetATF2
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Overview

  • Supplier
    Cusabio
  • Product Name
    ATF2 (Ab-472) Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID1386
  • Target name
    ATF2
  • Target description
    activating transcription factor 2
  • Target synonyms
    activating transcription factor 2 splice variant ATF2-var2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; CREB2; CREB-2; CRE-BP1; cyclic AMP-dependent transcription factor ATF-2; cyclic AMP-responsive element-binding protein 2; HB16; histone acetyltransferase ATF2; TREB7
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP15336
  • Protein Name
    Cyclic AMP-dependent transcription factor ATF-2
  • Scientific Description
    Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5-TGACGTCA-3) or to AP-1 (activator protein 1) consensus sequences (5-TGACTCA-3). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. Maekawa T., EMBO J. 8:2023-2028(1989). Yang L., J. Immunol. 158:2522-2525(1997). Hillier L.W., Nature 434:724-731(2005).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203