ATG3 (human) (rec.) (His)
AG-40B-0141
Product group Proteins / Signaling Molecules
Product AG-40B-0141 is not available
Product not available
There may be an alternative product available, please contact our technical support team.
Overview
- SupplierAdipoGen Life Sciences
- Product NameATG3 (human) (rec.) (His)
- Delivery Days Customer10
- CertificationResearch Use Only
- Concentration0.5 mg/ml
- Estimated Purity>95%
- Scientific DescriptionATG3 (Autophagy-related protein 3; APG3-like; PC3-96) is an ubiquitous member of the ATG3 family of proteins. It belongs to the autophagin protein family important in autophagy, the biological process which is involved in degradation of endogenous proteins and damaged organelles. ATG3 is an E2-like enzyme involved in the initial stages of autophagocytosis, autophagy and mitochondrial homeostasis. Autophagocytosis is a starvation-induced process responsible for the transport of cytoplasmic proteins to the lysosome/vacuole. It catalyzes the transfer of ATG7-bound ATG8 (LC3; GATE16; GABA-RAP in mammals) to phosphatidylethanolamine, which is essential for autophagy. It acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself. The ATG12 conjugation to ATG3 plays a role in mitochondrial homeostasis but not in autophagy. - Protein. Recombinant human ATG3 (aa 1-337) fused to a His-tag. Source: E. coli. Lyophilized from 20mM TRIS-HCl, pH 8.0, containing 150mM sodium chloride and protease inhibitor (Sigma S8830, 1 x concentration). Purity: >95% (SDS-PAGE). ATG3 (Autophagy-related protein 3; APG3-like; PC3-96) is an ubiquitous member of the ATG3 family of proteins. It belongs to the autophagin protein family important in autophagy, the biological process which is involved in degradation of endogenous proteins and damaged organelles. ATG3 is an E2-like enzyme involved in the initial stages of autophagocytosis, autophagy and mitochondrial homeostasis. Autophagocytosis is a starvation-induced process responsible for the transport of cytoplasmic proteins to the lysosome/vacuole. It catalyzes the transfer of ATG7-bound ATG8 (LC3; GATE16; GABA-RAP in mammals) to phosphatidylethanolamine, which is essential for autophagy. It acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself. The ATG12 conjugation to ATG3 plays a role in mitochondrial homeostasis but not in autophagy.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352202