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ATG3 (human) (rec.) (His)

Research Use Only
AG-40B-0141
AdipoGen Life Sciences
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    ATG3 (human) (rec.) (His)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Concentration
    0.5 mg/ml
  • Estimated Purity
    >95%
  • Scientific Description
    ATG3 (Autophagy-related protein 3; APG3-like; PC3-96) is an ubiquitous member of the ATG3 family of proteins. It belongs to the autophagin protein family important in autophagy, the biological process which is involved in degradation of endogenous proteins and damaged organelles. ATG3 is an E2-like enzyme involved in the initial stages of autophagocytosis, autophagy and mitochondrial homeostasis. Autophagocytosis is a starvation-induced process responsible for the transport of cytoplasmic proteins to the lysosome/vacuole. It catalyzes the transfer of ATG7-bound ATG8 (LC3; GATE16; GABA-RAP in mammals) to phosphatidylethanolamine, which is essential for autophagy. It acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself. The ATG12 conjugation to ATG3 plays a role in mitochondrial homeostasis but not in autophagy. - Protein. Recombinant human ATG3 (aa 1-337) fused to a His-tag. Source: E. coli. Lyophilized from 20mM TRIS-HCl, pH 8.0, containing 150mM sodium chloride and protease inhibitor (Sigma S8830, 1 x concentration). Purity: >95% (SDS-PAGE). ATG3 (Autophagy-related protein 3; APG3-like; PC3-96) is an ubiquitous member of the ATG3 family of proteins. It belongs to the autophagin protein family important in autophagy, the biological process which is involved in degradation of endogenous proteins and damaged organelles. ATG3 is an E2-like enzyme involved in the initial stages of autophagocytosis, autophagy and mitochondrial homeostasis. Autophagocytosis is a starvation-induced process responsible for the transport of cytoplasmic proteins to the lysosome/vacuole. It catalyzes the transfer of ATG7-bound ATG8 (LC3; GATE16; GABA-RAP in mammals) to phosphatidylethanolamine, which is essential for autophagy. It acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself. The ATG12 conjugation to ATG3 plays a role in mitochondrial homeostasis but not in autophagy.
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202