Atiprimod

MedChem Express

Atiprimod

9

Research Use Only

C22H44N2

336.60

Atiprimod (Azaspirane) is an orally bioavailable small molecule with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) by inhibiting the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Atiprimod also downregulates the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the PERK/eIF2alpha/ATF4/CHOP axis and inhibiting the nuclear translocation of STAT3/NF-kappaB transcription factors[1].

CCN(CCCN1CCC2(CCC(CCC)(CC2)CCC)C1)CC

12352200