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WB analysis of mouse brain membrane fraction extract using GTX30639 ATP7b antibody. Loading : 20μg
WB analysis of mouse brain membrane fraction extract using GTX30639 ATP7b antibody. Loading : 20μg
WB analysis of mouse brain membrane fraction extract using GTX30639 ATP7b antibody. Loading : 20μg

ATP7b antibody

GTX30639
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATP7B
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATP7b antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000. ICC/IF: 2 - 10 microg/ml. IHC-P: 1:100 - 1:500. IHC: 1:100 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID540
  • Target name
    ATP7B
  • Target description
    ATPase copper transporting beta
  • Target synonyms
    PWD, WC1, WD, WND, copper-transporting ATPase 2, ATPase, Cu(2+)- transporting, beta polypeptide, ATPase, Cu++ transporting, beta polypeptide, Wilson disease-associated protein, copper pump 2, copper-transporting protein ATP7B
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP35670
  • Protein Name
    Copper-transporting ATPase 2
  • Scientific Description
    This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • El Nachef L, Al-Choboq J, Bourguignon M, et al. Response of Fibroblasts from Menkes' and Wilson's Copper Metabolism-Related Disorders to Ionizing Radiation: Influence of the Nucleo-Shuttling of the ATM Protein Kinase. Biomolecules. 2023,13(12). doi: 10.3390/biom13121746
    Read this paper
  • Valtorta S, Belloli S, Sanvito F, et al. Comparison of 18F-fluoroazomycin-arabinofuranoside and 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) in preclinical models of cancer. J Nucl Med. 2013,54(7):1106-12. doi: 10.2967/jnumed.112.111120
    Read this paper
  • Roybal JL, Endo M, Radu A, et al. Early gestational gene transfer with targeted ATP7B expression in the liver improves phenotype in a murine model of Wilson's disease. Gene Ther. 2012,19(11):1085-94. doi: 10.1038/gt.2011.186
    Read this paper