
WB analysis of mouse brain membrane fraction extract using GTX30639 ATP7b antibody. Loading : 20μg
ATP7b antibody
GTX30639
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATP7B
Overview
- SupplierGeneTex
- Product NameATP7b antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000. ICC/IF: 2 - 10 microg/ml. IHC-P: 1:100 - 1:500. IHC: 1:100 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID540
- Target nameATP7B
- Target descriptionATPase copper transporting beta
- Target synonymsPWD, WC1, WD, WND, copper-transporting ATPase 2, ATPase, Cu(2+)- transporting, beta polypeptide, ATPase, Cu++ transporting, beta polypeptide, Wilson disease-associated protein, copper pump 2, copper-transporting protein ATP7B
- HostRabbit
- IsotypeIgG
- Protein IDP35670
- Protein NameCopper-transporting ATPase 2
- Scientific DescriptionThis gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- El Nachef L, Al-Choboq J, Bourguignon M, et al. Response of Fibroblasts from Menkes' and Wilson's Copper Metabolism-Related Disorders to Ionizing Radiation: Influence of the Nucleo-Shuttling of the ATM Protein Kinase. Biomolecules. 2023,13(12). doi: 10.3390/biom13121746Read this paper
- Valtorta S, Belloli S, Sanvito F, et al. Comparison of 18F-fluoroazomycin-arabinofuranoside and 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) in preclinical models of cancer. J Nucl Med. 2013,54(7):1106-12. doi: 10.2967/jnumed.112.111120Read this paper
- Roybal JL, Endo M, Radu A, et al. Early gestational gene transfer with targeted ATP7B expression in the liver improves phenotype in a murine model of Wilson's disease. Gene Ther. 2012,19(11):1085-94. doi: 10.1038/gt.2011.186Read this paper






