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ProductsBack/ATR antibody [2B5]

ATR antibody [2B5]

GTX70109
GeneTex
ApplicationsFunctional Assay, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetATR
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATR antibody [2B5] - Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Functional Assay, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2B5
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID545
  • Target name
    ATR
  • Target description
    ATR serine/threonine kinase
  • Target synonyms
    ataxia telangiectasia and Rad3-related protein; FCTCS; FRAP-related protein-1; FRP1; MEC1; MEC1, mitosis entry checkpoint 1, homolog; SCKL; SCKL1; serine/threonine-protein kinase ATR
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ13535
  • Protein Name
    Serine/threonine-protein kinase ATR
  • Scientific Description
    The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • New spirobisnaphthalenes from an endolichenic fungus strain CGMCC 3.15192 and their anticancer effects through the P53-P21 pathway. Li J et al., 2019 Nov 27, RSC Adv
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  • Novel modulators of p53-signaling encoded by unknown genes of emerging viruses. Alzhanova D et al., 2021 Jan, PLoS Pathog
    Read more
  • NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest. Sun X et al., 2020 Sep 18, Nucleic Acids Res
    Read more
  • RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Yenerall P et al., 2020 Jan 16, Cell Chem Biol
    Read more
  • IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2. Chen X et al., 2019 Jun, J Cancer Res Clin Oncol
    Read more
  • Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks. Burger K et al., 2019 Apr 23, Nucleic Acids Res
    Read more
  • The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells. Tu HJ et al., 2018 Dec 29, Clin Epigenetics
    Read more
  • Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. Chen CC et al., 2018 Sep 10, Cancers (Basel)
    Read more
  • TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice. Hu L et al., 2018 Mar 15, J Immunol
    Read more
  • Checkpoint kinase 2 is dispensable for regulation of the p53 response but is required for G2/M arrest and cell survival in cells with p53 defects under heat stress. Furusawa Y et al., 2017 Oct, Apoptosis
    Read more