[Au(L4)(CyJohnPhos)]SbF6

MedChem Express

[Au(L4)(CyJohnPhos)]SbF6

9

Research Use Only

C44H56AuF6NO4PSSb

1158.68

[Au(L4)(CyJohnPhos)]SbF6 is a gold containing complex. [Au(L4)(CyJohnPhos)]SbF6 inhibits cyclooxygenase-1/2 (COX-1/2), inhibits the proliferation (IC50 is 0.98 microM) and induces apoptosis in colon cancer cell Caco2-/TC7. [Au(L4)(CyJohnPhos)]SbF6 is also an inhibitor for thioredoxin reductase (TrxR), thereby exhibits antioxidant activity by modulating ROS levels[1].

COC1=CC2=C(C=C1)C=C([C@H](C)C(NC(CC[S]([Au+][P](C3CCCCC3)(C4CCCCC4)C5=CC=CC=C5C6=CC=CC=C6)C)C(OC)=O)=O)C=C2.F[Sb](F)(F)(F)F.[F-]

12352200