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ProductsBack/Auranofin [34031-32-8]
Chemical Structure
Chemical Structure
Chemical Structure

Auranofin [34031-32-8]

Research Use Only
AG-CR1-3611
AdipoGen Life Sciences
CAS Number34031-32-8
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Product group Chemicals
Estimated Purity>95%
Molecular Weight678.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Auranofin [34031-32-8]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    34031-32-8
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C20H34AuO9PS
  • Molecular Weight
    678.5
  • Scientific Description
    Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1beta pathway. Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKbeta subunit 5. Potent thioredoxin reductase (TrxR) inhibitor. Induces mitochondrial membrane permeability transition. Anti-cancer compound with anti-proliferative activity. Shown to induce apoptosis and necrosis. STAT3 and telomerase activity inhibitor. Proteasomal deubiquitinase inhibitor. Antibiotic, antiviral and antiparasitic compound. Immunosuppressive. - Chemical. CAS: 34031-32-8. Formula: C20H34AuO9PS. MW: 678.5. Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1beta pathway. Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKbeta subunit 5. Potent thioredoxin reductase (TrxR) inhibitor. Induces mitochondrial membrane permeability transition. Anti-cancer compound with anti-proliferative activity. Shown to induce apoptosis and necrosis. STAT3 and telomerase activity inhibitor. Proteasomal deubiquitinase inhibitor. Antibiotic, antiviral and antiparasitic compound. Immunosuppressive.
  • SMILES
    CCP(CC)(CC)=[Au]SC1OC(COC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • Auranofin. New oral gold compound for treatment of rheumatoid arthritis: A.E. Finkelstein, et al.; Ann. Rheum. Dis. 35, 251 (1976)
  • Inhibition of alveolar macrophage 5-lipoxygenase metabolism by auranofin: M. Peters-Golden & C. Shelly; Biochem. Pharmacol. 38, 1589 (1989)
  • Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit: K.I. Jeon, et al.; Exp. Mol. Med. 35, 61 (2003)
  • Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells: C. Marzano, et al.; Free Radic. Biol. Med. 42, 872 (2007)
  • Auranofin, an immunosuppressive drug, inhibits MHC class I and MHC class II pathways of antigen presentation in dendritic cells: S. Han, et al.; Arch. Pharm. Res. 31, 370 (2008)
  • The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-kappaB activity: A. Nakaya, et al.; Leuk. Res. 35, 243 (2011)
  • The biological activity of auranofin: implications for novel treatment of diseases: J.M. Madeira, et al.; Inflammopharmacology 20, 297 (2012) (Review)
  • Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells: N.H. Kim, et al.; BMB Rep. 46, 59 (2013)
  • Drug repositioning: auranofin as a prospective antimicrobial agent for the treatment of severe staphylococcal infections: M.I. Cassetta, et al.; Biometals 27, 787 (2014)
  • Suppression of the pro-inflammatory NLRP3/interleukin-1beta pathway in macrophages by the thioredoxin reductase inhibitor auranofin: E. Isakov, et al.; Biochim. Biophys. Acta 1840, 3153 (2014)