Australine (hydrochloride) [186766-07-4]

TargetMol Chemicals

Australine (hydrochloride) [186766-07-4]

44

186766-07-4

Chemical

Research Use Only

Australine (hydrochloride)

C8H16ClNO4

225.67

Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 microM) that also inhibits glucosidase I, sucrase, maltase, andA. nigeralpha-glucosidase (IC50s = 20, 28, 35, and 28 microM, respectively).2,3Australine is selective for these enzymes over glucosidase II, alpha- and beta-mannosidase, and alpha- and beta-galactosidase up to 500 microM, beta-glucosidase, with only 5% inhibition at 66 microM, as well as isomaltase and trehalase (IC50= 97 and 160 microM, respectively). Australine (500 microg/ml) inhibits glycoprotein processing of viral glycoproteins in influenza virus-infected MDCK cells and induces the accumulation of glycoproteins.2

3 years

Cl.[H][C@]12[C@@H](O)CCN1[C@H](CO)[C@@H](O)[C@@H]2O

-20°C

12352200