AZ0108

MedChem Express

AZ0108

5

C24H20F4N6O2

500.45

AZ0108 is an inhibitor for poly ADP-ribose polymerase ( PARP ), which inhibits PARP1, PARP2, PARP3, PARP6, TNKS1, TNKS2, with IC 50 s of 3 microM, respectively. AZ0108 prevents centrosome clustering with an EC 50 of 0.053 microM, and exhibits cytotoxicity in cell OCI-LY-19 with GI 50 of 0.017 microM. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models [1] .

O=C(C1=CC(C(F)(C(C2=CC=CC=C23)=NNC3=O)F)=CC=C1)N4CC5=NN=C(C(F)(C)F)N5C[C@@H]4C

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