AZ12672857

MedChem Express

AZ12672857 [945396-55-4]

10

945396-55-4

Research Use Only

98.44

C26H30N8O2

486.57

AZ12672857 is an orally active inhibitor of EphB4 ( IC 50 =1.3 nM) and Src kinases . AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC 50 =2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC 50 =9 nM) [1] .

CN(C1=CC=CC2=C1C=NN2)C3=NC(NC4=CC(N5CCOCC5)=CC(N6CCOCC6)=C4)=NC=C3

-20°C,2°C to 8°C

12352200