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ProductsBack/AZD-5363 [1143532-39-1]

AZD-5363 [1143532-39-1]

Research Use Only
A9601
LKT Laboratories
Estimated Purity≥99%, ≥99%ee
Product group Chemicals
€ 130,00
1 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    AZD-5363 [1143532-39-1]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥99%, ≥99%ee
  • Format
    In DMSO(86mg/ml), water with 2 eq. of acid, insoulble on ethanol
  • Scientific Description
    AKT inhibitor, potential ROCK, p70S6K, PKA, MKK1, MSK1, MSK2, PKC, PKG, PRKX, RSK2/3 inhibitor.; AZD5363
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Addie M, Ballard P, Buttar D, et al. Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. J Med Chem. 2013 Mar 14;56(5):2059-73. PMID: 23394218. Lamoureux F, Thomas C, Crafter C, et al. Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363. Clin Cancer Res. 2013 Feb 15;19(4):833-44. PMID: 23258740. Davies BR, Greenwood H, Dudley P, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87. PMID: 22294718.