AZD1080 [612487-72-6]

Biorbyt

AZD1080 [612487-72-6]

16

612487-72-6

Research Use Only

C19H18N4O2

334.3718

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3alpha and GSK3beta with Ki of 6.9 nM and 31 nM, respectively, shows > 14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

O1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N=C(C([H])=C2[H])C2=C(N([H])C3C([H])=C([H])C(C#N)=C([H])C2=3)O[H])C([H])([H])C1([H])[H]

12352200