BACE1-IN-13

MedChem Express

BACE1-IN-13

14

Research Use Only

C20H17FN8O2

420.40

BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAbeta42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Abeta42 reduction in mouse and dog animal models[1].

C[C@@]1(C2=CC(NC(C3=NC=C(OC)N=C3)=O)=CC=C2F)CN4C(C(N)=N1)=CC(C#N)=N4

12352200