BAG3 Polyclonal Antibody
RD81924A
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetBAG3
Overview
- SupplierReddot Biotech
- Product NameBAG3 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoHistoChemistry
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID9531
- Target nameBAG3
- Target descriptionBAG cochaperone 3
- Target synonymsBAG family molecular chaperone regulator 3; BAG-3; BCL2 associated athanogene 3; BCL2-binding athanogene 3; bcl-2-binding protein Bis; Bcl-2-binding protein BIS transcript 2; BIS; CAIR-1; docking protein CAIR-1; MFM6
- HostRabbit
- IsotypeIgG
- Scientific DescriptionBAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203