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ProductsBack/Bakuchiol [10309-37-2]
Chemical Structure
Chemical Structure
Chemical Structure

Bakuchiol [10309-37-2]

Research Use Only
AG-CN2-0495
AdipoGen Life Sciences
CAS Number10309-37-2
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Product group Chemicals
Estimated Purity>98%
Molecular Weight256.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Bakuchiol [10309-37-2]
  • Delivery Days Customer
    10
  • CAS Number
    10309-37-2
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C18H24O
  • Molecular Weight
    256.4
  • Scientific Description
    Antibiotic. Antimicrobial, anti-inflammatory, anticancer and immunosuppressive compound. Shown to have hepatoprotective and hypoglycemic activity. Apoptosis inducer in cancer cells. Sensitizes cancer cells. Induces cell cycle arrest. Antiviral agent. Inhibited influenza A viral infection and growth through activation of Nrf2. Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression via inactivation of NF-kappaB. DNA polymerase and UDP-glucuronosyltransferase inhibitor. Anti-aging compound with retinol-like effects on gene expression and properties of the skin. Phospholipase A, cyclooxygenase-1 (COX-1) and HIF-1 inhibitor. - Chemical. CAS: 10309-37-2. Formula: C18H24O. MW: 256.4. Isolated from Psoralea corylifolia. Antibiotic. Antimicrobial, anti-inflammatory, anticancer and immunosuppressive compound. Shown to have hepatoprotective and hypoglycemic activity. Apoptosis inducer in cancer cells. Sensitizes cancer cells. Induces cell cycle arrest. Antiviral agent. Inhibited influenza A viral infection and growth through activation of Nrf2. Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression via inactivation of NF-kappaB. DNA polymerase and UDP-glucuronosyltransferase inhibitor. Anti-aging compound with retinol-like effects on gene expression and properties of the skin. Phospholipase A, cyclooxygenase-1 (COX-1) and HIF-1 inhibitor.
  • SMILES
    OC1=CC=C(/C=C/[C@](C)(C=C)CC/C=C(C)/C)C=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998)
  • Isolation and antihyperglycemic activity of bakuchiol from Otholobium pubescens (Fabaceae), a Peruvian medicinal plant used for the treatment of diabetes: J.M. Krenisky, et al.; Biol. Pharm. Bull. 22, 1137 (1999)
  • Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med. 66, 569 (2000)
  • In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother. 45, 3009 (2001)
  • Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol. 1, 1849 (2001)
  • Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med. 67, 750 (2001)
  • Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002)
  • Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot. 62, 389 (2005)
  • In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005)
  • Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007)