Bax agonist 1

MedChem Express

Bax agonist 1

9

Research Use Only

C8H16N4

168.24

Bax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research[1].

N12CN(CC2)CN(C3)CCN3C1

12352200