BAZ2A Antibody

Cusabio

BAZ2A Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on Lys-16 (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity. Jones M.H., Genomics 63:40-45(2000). Bechtel S., BMC Genomics 8:399-399(2007). Scherer S.E., Nature 440:346-351(2006).

Human

-20°C or -80°C

12352203