BC-LI-0186
HY-136265
Overview
- SupplierMedChem Express
- Product NameBC-LI-0186 [695207-56-8]
- Delivery Days Customer10
- CAS Number695207-56-8
- CertificationResearch Use Only
- Estimated Purity99.20
- Molecular FormulaC22H27N3O4S
- Molecular Weight429.53
- Scientific DescriptionBC-LI-0186 is a potent and selective inhibitor of Leucyl-tRNA synthetase (LRS; LeuRS) and Ras-related GTP-binding protein D (RagD) interaction ( IC 50 =46.11 nM). BC-LI-0186 competitively binds to the RagD interacting site of LRS ( K d =42.1 nM) and has on effects on LRS-Vps34, LRS-EPRS, RagB-RagD association, mTORC1 complex formation or the activities of 12 kinases. BC-LI-0186 can effectively suppress the activity of cancer-associated?MTOR?mutants and the growth of rapamycin-resistant cancer cells.?BC-LI-0186 is a promising agent for lung cancer research [1] [2] .
- SMILESO=S(C1=CC=C(N2N(C)C(C)=C(C(C)C)C2=O)C=C1)(NCCOC3=CC=CC=C3)=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200