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BC-LI-0186

HY-136265
MedChem Express
CAS Number695207-56-8
Product group Chemicals
Estimated Purity99.20
Molecular Weight429.53
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Overview

  • Supplier
    MedChem Express
  • Product Name
    BC-LI-0186 [695207-56-8]
  • Delivery Days Customer
    10
  • CAS Number
    695207-56-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.20
  • Molecular Formula
    C22H27N3O4S
  • Molecular Weight
    429.53
  • Scientific Description
    BC-LI-0186 is a potent and selective inhibitor of Leucyl-tRNA synthetase (LRS; LeuRS) and Ras-related GTP-binding protein D (RagD) interaction ( IC 50 =46.11 nM). BC-LI-0186 competitively binds to the RagD interacting site of LRS ( K d =42.1 nM) and has on effects on LRS-Vps34, LRS-EPRS, RagB-RagD association, mTORC1 complex formation or the activities of 12 kinases. BC-LI-0186 can effectively suppress the activity of cancer-associated?MTOR?mutants and the growth of rapamycin-resistant cancer cells.?BC-LI-0186 is a promising agent for lung cancer research [1] [2] .
  • SMILES
    O=S(C1=CC=C(N2N(C)C(C)=C(C(C)C)C2=O)C=C1)(NCCOC3=CC=CC=C3)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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BC-LI-0186 [695207-56-8]
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