BChE/HDAC6-IN-2

MedChem Express

BChE/HDAC6-IN-2

14

Research Use Only

C27H30N4O4

474.55

BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.

O=C(NCC1=CC=CC=C1CN(CC)CC)C2=CC(NC(C3=CC(C(NO)=O)=CC=C3)=O)=CC=C2

12352200