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Bcl6 Antibody

Research Use Only
ORB606836
Biorbyt
ApplicationsImmunoHistoChemistry
Product group Antibodies
Price on request
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More than 130 suppliers
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Overview

  • Supplier
    Biorbyt
  • Product Name
    Bcl6 Antibody
  • Delivery Days Customer
    16
  • Applications
    ImmunoHistoChemistry
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P
  • Certification
    Research Use Only
  • Clone ID
    rBCL6/1718
  • Isotype
    IgG
  • Scientific Description
    Antibody to Bcl-6 is helpful in a number of diagnostic settings: First, in the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show Bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. Second, Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, Bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. Third, Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
  • UNSPSC
    12352203