BCR-ABL-IN-5 [1795736-60-5]

MedChem Express

BCR-ABL-IN-5 [1795736-60-5]

10

1795736-60-5

Research Use Only

C25H21Cl2N5O2

494.37

BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 microM and 0.45 microM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells[1].

NC1=NNC2=C1C(C3=CC=C(C=C3)C(N4CCN(CC4)C(C5=C(C=C(C=C5)Cl)Cl)=O)=O)=CC=C2

12131703