Bestrophin 1 antibody

GeneTex

Bestrophin 1 antibody

7

This antibody was raised against mouse BEST1 Extracellular domain.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application

Research Use Only

Polyclonal

0.8 mg/ml

Unconjugated

Best1

bestrophin 1

best macular dystrophy; bestrophin-1; Bmd; mBest; mBest1; vitelliform macular dystrophy 2 homolog; vitelliform macular dystrophy protein 2 homolog; Vmd; Vmd2

Rabbit

IgG

Bestrophin-1

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203