beta Catenin antibody [6F9]

GeneTex

beta Catenin antibody [6F9]

9

The antibody does not cross-react with plakoglobin (γ-catenin).

WB: 1:1,000. ICC/IF: 1:1,000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

6F9

Unconjugated

CTNNB1

catenin beta 1

beta catenin; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CHBCAT

Mouse

IgG1

The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 protooncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Bovine, Canine, Chicken, Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203