beta-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE

MedChem Express

beta-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE

14

Research Use Only

C59H92N8O19

1217.40

beta-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against beta-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects[1].

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