Beta Lactoglobulin antibody, PAb

Biorbyt

Beta Lactoglobulin antibody, PAb

16

Dot Blot, ImmunoElectrophoresis, ImmunoPrecipitation

DOT, IEP, IP

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Precipitating polyclonal rabbit antiserum to bovine beta-lactoglobulin. Beta-lactoglobulin is the dominant protein in bovine milk, synthesized in mammary gland tissue. It is a glycoprotein present mainly as a dimer at intermediate concentrations near the isoelectric point. The molecular weight of the monomeric subunit is near 17,000. It is very sensitive to denaturation. Any treatment of native milk and also prolonged storage in the deepfreeze will lead first to polymerization (octamers and higher polymers) aggregation and finally to denaturation. Three genetic variants A, B and C have been identified. They differ very little in the amino acid constellation an their behavior under pH and temperature various conditions. No immunological differences was found between the variants. Beta-lactoglobulin can be purified in crystallized form. Allergic reactions of infants to bovine milk proteins are well known. The actual process by which such reactions develop and their impact on the infants health have not been unambiguously established. Circulating antibodies to beta-lactoglobulin have been demonstrated in sera of some infants. Freunds complete adjuvant is used in the first step of the immunization procedure.

Beta-lactoglobulin is the dominant protein in bovine milk, synthesized in mammary gland tissue. It is a glycoprotein present mainly as a dimer at intermediate concentrations near the isoelectric point. The molecular weight of the monomeric subunit is near

Bovine

2°C to 8°C,-20°C

12352203