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beta-Naphthoflavone-CH2-OH
T17363
Overview
- SupplierTargetMol Chemicals
- Product Namebeta-Naphthoflavone-CH2-OH
- Delivery Days Customer16
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical Namebèta-Naphthoflavone-CH2-OH
- Molecular FormulaC20H14O3
- Molecular Weight302.32
- Scientific Descriptionbeta-Naphthoflavone-CH2-OH (beta-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., beta-naphthoflavone-JQ1). These chimeric molecules recruit the AhR E3 ligase complex by incorporating AhR ligands. By inducing ubiquitination-mediated degradation, PROTACs effectively target and degrade cancer-promoting proteins [1].
- Shelf life instruction3 years
- SMILESO=C1C=C(C2=CC=C(CO)C=C2)OC3=C1C4=CC=CC=C4C=C3
- Storage Instruction-20°C
- UNSPSC12352200
References
- Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins. Ohoka N et al., 2019 Dec 20, ACS Chem BiolRead more