beta-Sheet Breaker Peptide iAbeta5

MedChem Express

beta-Sheet Breaker Peptide iAbeta5 [182912-74-9]

10

Research Use Only

99.92

beta-Sheet Breaker Peptide iAbeta5 is an effective brain amyloid-beta (Abeta) degrader. Abeta deposits are associated with Alzheimers disease (AD), and the related toxicity arises from its beta-sheet conformation and aggregation. beta-Sheet Breaker Peptide iAbeta5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, beta-Sheet Breaker Peptide iAbeta5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. beta-Sheet Breaker Peptide iAbeta5 can reduce the size and/or number of brain amyloid plaques in AD. beta-Sheet Breaker Peptide iAbeta5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

-20°C,-80°C

12352202