beta-Sheet Breaker Peptide iAbeta5 [182912-74-9]

MedChem Express

beta-Sheet Breaker Peptide iAbeta5 [182912-74-9]

10

Research Use Only

99.92

beta-Sheet Breaker Peptide iAbeta5 is a potent degrader of cerebral amyloid-beta (Abeta). Abeta deposition is associatied with the Alzheimer disease (AD), due to its related toxicity linked to its beta-sheet conformation and/or aggregation. beta-Sheet Breaker Peptide iAbeta5 reproducibly induces in vivo disassembly of fibrillar amyloid deposits. Thus, beta-Sheet Breaker Peptide iAbeta5 prevents and/or reverses neuronal shrinkage caused by Abeta, and reduces the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. beta-Sheet Breaker Peptide iAbeta5 reduces the size and/or number of cerebral amyloid plaques in AD. beta-Sheet Breaker Peptide iAbeta5 labeled by hydrophobic benzyl alcohol (HBA) tag, can be used for quantitative assay by showing vivid blue color under acidic conditions[1][2][3].

-20°C,-80°C

12352202