beta Tubulin 4 antibody [ONS.1A6]

GeneTex

beta Tubulin 4 antibody [ONS.1A6]

9

WB: 1:400. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

ONS.1A6

Unconjugated

TUBB4A

tubulin beta 4A class IVa

beta-5; dystonia 4, torsion (autosomal dominant); DYT4; TUBB4; tubulin beta-4 chain; tubulin beta-4A chain; tubulin, beta 4; tubulin, beta, 5

Mouse

IgG1

Tubulin beta-4A chain

The major building block of microtubules is tubulin, an intracellular cylindrical filamentous structure that is present in almost all eukaryotic cells. Except in the simplest eukaryotes, tubulin exists in all cells as a 100 kD protein, a heterodimer of two similar but not identical polypeptides, designated alpha and beta, that assembles into microtubules. Both alpha and beta tubulins consist of various isotypes. For beta tubulin, six evolutionarily conserved isotypes were identified (designated beta I-beta VI). Beta IV exists as two subtypes in mammals, differing from each other at 10 positions. beta IVa is brain specific, whereas beta IVb is ubiquitous, and both appear to be constitutive. The detection, localization and characterization of proteins involved in microtubule function is fundamental to the understanding of mitosis, meiosis, organellar and flagellar movement, intracellular transport, and cytoskeletal functions.

-20°C or -80°C,2°C to 8°C

12352203